姓 名：周伶俐
研究方向：（1）肿瘤、炎症性疾病发病机制；（2）转录后、蛋白翻译后修饰调控在疾病过程中作用机制；（3）固有免疫调控机制
工作经历
2023.09-至今 暨南大学，生命科学与技术学院
2021.06-2023.08 深圳市罗湖区人民医院，精准医学研究院，博士后
2018.03-2021.04 中山大学，生命科学学院，博士后
2017.07-2018.03 湖南师范大学，生命科学学院
教育经历
2014.09-2017.06 中国科学院大学，海洋生物学，博士
2011.09-2014.06 中国地质大学（武汉），生物化学与分子生物学，硕士
2007.09-2011.06 中国地质大学（武汉），生物科学，学士
科研项目
l国家自然科学基金（青年科学基金项目），32000544，去SUMO化修饰酶SENP6调控抗病毒免疫反应和自噬crosstalk的分子机制研究，2021-01至2023-12，在研，主持
l中国博士后科学基金第71批面上资助，2022M710902，去SUMO化酶SENP6促进M2巨噬细胞极化调控膀胱癌进展的分子机制，2022-6至2023-12，结题，主持
l中央高校基本科研业务费-青年教师培育项目，19lgpy198，新发突变促进其去泛素化导致自身炎症性疾病的机制研究，2019-01至2021-12，结题，主持
l中国博士后科学基金第64批面上资助（一等），2018M640853，RGNNV感染细胞的核酸适配体靶向运载siRNA的抗病毒研究，2018-11至2020-11，结题，主持
l重大研究计划，92042303，儿童肠肝免疫稳态的维持机制研究， 2021-01至2022-12，150万元，结题，参与
代表性论文
l Zhang L#, Li Y#, Zhou L#, Zhou H, Zhou Z, Wu K, Yan Z, Thiery JP, Cui J, Wu S*；The m6A reader YTHDF2 promotes bladder cancer progression by suppressing RIG-I-mediated immune response. Cancer Research, 2023, 83(11):1834-1850.
l Zhou L#, He Xing#, Wang L, et al. Palmitoylation restricts SQSTM1/p62-mediated autophagic degradation of NOD2 to modulate inflammation. Cell death & Differenciation, 2022, 29:1541-51.
l Zhou L#, Liu T#, Huang B#, et al. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. Journal of Allergy and Clinical Immunology, 2021, 147: 267-279.
l Zhou L, Zeng H*, Cui J*, Jin S*. Palmitoylation facilitates inflammation through suppressing NOD2 degradation mediated by the selective autophagy receptor SQSTM1. Autophagy, 2022, 18: 2254-5 (Punctum).
l Zhou H#, Zhang L#, Luo W, Hong H, Tang D, Zhou D, Zhou L*, Li Y*. AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma. Frontiers in Pharmacology. 2022:4653.
l Zhou L, Li P, Yang M, et al. Generation and characterization of novel DNA aptamers against coat protein of grouper nervous necrosis virus (GNNV) with antiviral activities and delivery potential in grouper cells. Antiviral Research, 2016, 129: 104-114.
l Zhou L, Wang S, Yu Q，et al. Characterization of novel aptamers specifically directed to red-spotted grouper nervous necrosis virus (RGNNV)- infected cells for mediating targeted siRNA delivery. Frontiers in Microbiology, 2020, 11:660.
l Zhou L#, Li P#, Yu Y, et al. Rapid and sensitive detection of redspotted grouper nervous necrosis virus (RGNNV) infection by aptamer-coat protein-aptamer sandwich enzyme-linked apta-sorbent assay (ELASA). Journal of Fish Diseases, 2017, 40:1831-1838.
l Zhou L#, Li P#, Liu J, et al. Establishment and characterization of a mid-kidney cell line derived from golden pompano Trachinotus ovatus, a new cell model for virus pathogenesis and toxicology studies. In Vitro Cellular & Developmental Biology-Animal, 2017, 53:320-327.
l Li P#, Zhou L#, Wei J, et al. Development and characterization of aptamer-based enzyme-linked apta-sorbent assay for the detection of Singapore grouper iridovirus infection. Journal of applied microbiology, 2016, 121: 634-643.
l Li P#, Yu Qing#, Zhou L#, et al. Probing and characterizing the high specific sequences of ssDNA aptamer against SGIV-infected cells. Virus Research, 2018, 246: 46-54.
l Li P#, Zhou L#, Yang M, et al. Establishment and characterization of a cell line from the head kidney of Golden pompano (Trachinotus ovatus), and its application in toxicology and virus susceptibility，Journal of Fish Biology, 2017, 90: 1944-1959.
l Mu Y#, Zhou L#, Zeng X C, et al. Arsenicitalea aurantiaca gen. nov., sp. nov., a new member of the family Hyphomicrobiaceae, isolated from the high-arsenic sediment in Jianghan Plain. International Journal of Systematic and Evolutionary Microbiology, 2016, 66: 5478-5484.
专利
l吴松，周伶俐，张磊，周厚宏，李宇清（2023103702132）：含自由三磷酸基团的YTHDF2特异性siRNA及其应用
l秦启伟，周伶俐，李鹏飞，魏世娜（CN106916821B）：一种ssDNA核酸适配体及其应用
l秦启伟，李鹏飞，魏世娜，杨敏，周伶俐，俞也频 （CN104789570B）：一种用于检测石斑鱼虹彩病毒感染的DNA核酸适配体及其筛选方法和应用。
