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李筠 副教授

日期: 2023-05-08


李筠,女,福建福州人,理学博士。现任免疫生物学系副教授,硕士生导师。

学术方向:以肺癌和胃癌为疾病模型,研究肿瘤免疫微环境重塑的调控机制及诊疗策略。迄今发表SCI研究论文18篇,其中第一或通讯作者论文11篇,包括Nature Communications, Cancer Research2篇),the Journal of Pathology2篇)等权威期刊。所发表论文累计被引733次,单篇最高被引144次。主持国家自然科学基金2项,广东省自然科学基金面上项目1项,广州市科技计划基础研究计划1项等。兼任暨南大学科学技术协会第一届会员,中华医学会福建省微生物与免疫学分会青年委员。

 

教育及工作经历

2005.9 - 2009.6  山东大学生命科学学院  学士

2009.9 - 2014.6  中山大学中山医学院    博士

2014.8 - 2016.8  福建医科大学基础医学院 病原生物学系

2016.8 - 至今   暨南大学生命科学技术学院 免疫生物学系

 

研究论文

代表性论文:

Ting Dai#, Xin Zhang#, Xiang Zhou#, Xiaodi Huang, Xiaoxia Hu, Feiyue Xing, Han Tian*, Yun Li*. LncRNA VAL facilities PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer. Clinical and Translational Medicine, 2022, 12(10): e1088.(通讯作者,中科院1TopIF=8.554

Yun Li#,*, Chenying Liu#, Xin Zhang, Xiaodi Huang, Shujun Liang, Feiyue Xing*, Han Tian*. CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway. British Journal of Cancer, 2022, 126(12): 1684-1694.(第一/共同通讯作者,中科院1TopIF=9.075

Han Tian#, Rong Lian#, Yun Li#, Chenying Liu, Shujun Liang, Wei Li, Tianyu Tao, Xingui Wu, Yaokai Ye, Xia Yang, Jian Han, Xuwei Chen, Jun Li, Yukai He, Mengfeng Li, Jueheng Wu*, Junchao Cai*. AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation. Nature Communications, 2020, 11(1): 5127.(共同第一作者,中科院1TopIF=17.694

Yun Li#, Liwen Deng#, Xiaohui Zhao#, Bohan Li, Dong Ren, Lihong Yu, Hehai Pan, Qing Gong, Libing Song, Xiang Zhou*, Ting Dai*. Tripartite motif‐containing 37 promotes the aggressiveness of non‐small‐cell lung cancer cells by activating the NF-κB pathway. The Journal of Pathology, 2018, 246(3): 366-378.(第一作者,中科院1TopIF=9.883

Yun Li#, Xiaoli Yan#, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin*, Xu Lin*. Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling. BMC Cancer, 2019, 19(1): 505.(第一作者,中科院2TopIF=4.638

Jianxin Ye#, Jinsheng Huang#, Jie Xu, Qiang Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Yun Li*, Xu Lin*. ERp29 controls invasion and metastasis of gastric carcinoma by inhibition of epithelial-mesenchymal transition via PI3K/Akt signaling pathway. BMC Cancer, 2017, 17(1): 626.(共同通讯作者,中科院2TopIF=4.638

Ting Dai#, Xiaohui Zhao#, Yun Li#, Lihong Yu, Yanan Li, Xiang Zhou*, Qing Gong*. miR-423 promotes breast cancer invasion by activating NF-κB signaling. OncoTargets and Therapy, 2020, 13: 5467-5478.(共同第一作者,中科院3区,IF=4.345

Yong Peng, Jiaoying Jia, Zhongzhong Jiang, Dezhi Huang, Yugang Jiang*, Yun Li*. Oncogenic DIRAS3 promotes malignant phenotypes of glioma by activating EGFR-AKT signaling. Biochemical and Biophysical Research Communications, 2018, 505(2): 413-418.(通讯作者,中科院3区,IF=3.322

Yun Li, Wei Li, Zhe Ying, Han Tian, Xun Zhu, Jun Li, Mengfeng Li*. Metastatic Heterogeneity of Breast Cancer Cells Is Associated with Expression of a Heterogeneous TGF beta-Activating miR424-503 Gene Cluster. Cancer Research, 2014, 74(21): 6107-18.(第一作者,中科院1TopIF=13.312

Zhe Ying#, Yun Li#, Jueheng Wu, Xun Zhu, Yi Yang, Han Tian, Wei Li, Bo Hu, Shi-Yuan Cheng, Mengfeng Li*. Loss of miR-204 expression enhances glioma migration and stem cell-like phenotype. Cancer Research, 2013, 73(2): 990-9.(共同第一作者,中科院1TopIF=13.312

Libing Song#,*, Lan Wang#, Yun Li#, Huaping Xiong, Jueheng Wu, Jun Li, Mengfeng Li*. Sam68 up-regulation correlates with, and its down-regulation inhibits, proliferation and tumourigenicity of breast cancer cells. The Journal of Pathology, 2010, 222(3): 227-37.(共同第一作者,中科院1TopIF=9.883

其他论文:

Zhe Ying#, Han Tian#, Yun Li, Rong Lian, Wei Li, Shanshan Wu, Hui-Zhong Zhang, Jueheng Wu, Lei Liu, Junwei Song, Hongyu Guan, Junchao Cai, Xun Zhu, Jun Li, Mengfeng Li*. CCT6A suppresses SMAD2 and promotes prometastatic TGF-β signaling. The Journal of Clinical Investigation, 2017, 127(5): 1725-1740.(中科院1TopIF=19.486

JiaBin Wang#, ZuWei Wang#, Yun Li, ChaoQun Huang, ChaoHui Zheng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Yao Lin*, ChangMing Huang*. CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling. Cancer Letters, 2017, 385: 188-197.(中科院1TopIF=9.756

Jianxin Ye#, Jie Xu#, Yun Li, Qiang Huang, Jinsheng Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Wannan Chen*, Xu Lin*. DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β‐catenin signaling pathway. Molecular Oncology, 2017, 11(9): 1208-1224.(中科院2区,IF=7.449

Liping Liu#, Hongyu Guan#, Yun Li, Zhe Ying, Jueheng Wu, Xun Zhu, Libing Song, Jun Li*, Mengfeng Li*. Astrocyte elevated gene 1 interacts with acetyltransferase p300 and c-Jun to promote tumor aggressiveness. Molecular and Cellular Biology, 2017, 37(5): e00456-16.(中科院3区,IF=5.124

Ping Li*, Xi Lin, JunRong Zhang, Yun Li, Jun Lu, FeiChao Huang, ChaoHui Zheng, JianWei Xie, JiaBin Wang, ChangMing Huang*. The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer. Oncotarget, 2016, 7(9):10650-62.IF=5.168

Haiyin Zheng#, Fuxing Zhang#, Xinjian Lin, Changming Huang, Yiqin Zhang, Yun Li, Jianyin Lin, Wannan Chen*, Xu Lin*. MicroRNA-1225-5p inhibits proliferation and metastasis of gastric carcinoma through repressing insulin receptor substrate-1 and activation of beta-catenin signaling. Oncotarget, 2016, 7(4):4647-63.IF=5.168

Libing Song#, Liping Liu#, Zhiqiang Wu, Yun Li, Zhe Ying, Chuyong Lin, Jueheng Wu, Bo Hu, Shi-Yuan Cheng, Mengfeng Li, Jun Li*. TGF-beta induces miR-182 to sustain NF-kappa B activation in glioma subsets. The Journal of Clinical Investigation, 2012, 122(10): 3563-78.(中科院1TopIF=19.486

 

主持科研项目

国家自然科学基金面上项目,TRIM11/IL-33轴驱动非小细胞肺癌溶骨性骨转移的机制研究,821732252022.01-2025.1254.70万元,在研

国家自然科学基金青年科学基金项目,miR-188-5p促进胃癌转移的机制研究,815021252016.01-2018.1219.00万元,已结题

广东省自然科学基金面上项目,TRIM11促进非小细胞肺癌淋巴结转移的机制研究,2022A15150122112022.01-2024.1210.00万元,在研

广州市科技计划基础研究计划,CCT6A调控Wnt/β-catenin信号通路驱动胃癌恶性进展的机制研究,2021020200222021.04-2023.035.00万元,在研

暨南大学科研培育与创新基金跃升计划,长非编码RNA GAPLINC激活TLR信号通路促进胃癌转移的机制研究,216174412017.01-2018.1212.00万元,已结题

暨南大学学科建设优秀青年骨干,2022年度,3.76万元


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