邢飞跃，医学博士，免疫学教授，博士生导师，免疫生物学系/组织移植与免疫研究中心主任。曾受训于中国医学科学院药物研究所韩锐教授和第一军医大学赵克森教授，在印度Bose Institute免疫学系做Research Scientist，在美国Duke University医学中心担任Protocol Principal Investigator。长期以来一直致力于通过基因表达调控与干预策略和细胞信号转导技术，探讨肿瘤免疫与生物治疗，免疫细胞分化与调控和自身免疫性疾病的分子机制及其治疗新法。曾主持完成国家自然科学基金项目、省自然科学基金项目、省市科技计划重大专项、省优秀科技人才专项10余项，主要参与完成美国NIH RO1项目3项，在国内外专业杂志上发表论文190余篇，参编专著和本科教材6部，培养硕、博士生和博士后64名。曾获省科技进步二等奖1项(排名第一)，其它省科技进步奖多项(排名第一至第四)。为国际基金项目(Trond Mohn Foundation) 二审评委、国家“863”项目、国家自然科学基金项目、广东省自然科学基金项目和省、市科技攻关项目评审专家，广东省免疫学会常务理事，广东省生物物理学会常务理事；兼任Clin J Allergy Immunol、Int J Immunol、J Clin Exp Immunol、SOJ Immunology、Front Mol Immunol、J Cancer Immunol、Am J Curr Biol、Am J Mol Cell Biol、Int J Hematol Res 和 J Basic Appl Sci 等国际专业杂志编委; 是Adv Sci, J Clin Invest, Int J Cancer, Cell Death Dis, FASEB J, Cell Immunol, Prog Biochem Biophys, Acta Biochim Biophys Sin 和 Chinese Med等20余种SCI杂志审稿人；美国免疫学家学会和美国生物化学与分子生物学学会会员。主要享有省政府特殊津贴，省卫生科技先进工作者，省第二届青年科技奖，市科技进步先进工作者和市优秀青年科技工作者等荣誉。
一．发表的主要论文
1. Characteristics of a novel photoinitiator aceanthrenequinone-initiated polymerization and cytocompatibility of its triggered polymer.Toxicology Reports, 2022, 9:191-203.
2.Commentary: PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules. Front Immunol. 2021,12:721344.
3.Cytotoxic and cytocompatible comparison among seven photoinitiators-triggered polymers in different tissue cells.Toxicol In Vitro. 2021, 72:105103.
4.CCT5 induces epithelial-mesenchymal transition to promote gastric cancer lymph node metastasis by activating the Wnt/β-catenin signalling pathway. Br J Cancer. 2022,126(12):1684-1694.
5.Photoinduced free radical-releasing systems and their anticancer properties. Photochem Photobiol Sci. 2022, 21(8):1405-1417.
6.Polymer-coated calcium peroxide nanoparticles as an oxygen self-supplying platform for enhanced photodynamic therapy. European Polymer Journal. 177 (2022) 111458
7.Degradable Hydrogel Adhesives with Enhanced Tissue Adhesion, Superior Self-Healing, Cytocompatibility, and Antibacterial Property. Adv Healthc Mater. 2022,11(4):e2101504.
8.Radical Ring-Opening Single Unit Monomer Insertion: An Approach to Degradable and Biocompatible Sequence-Defined Oligomers. Macromolecules, 2021, 54:10923−10930.
9. PhotoATRP Approach to Poly(methyl methacrylate) with Aggregation-Induced Emission. Ind Eng Chem Res, 2021, 60:7024-7032.
10.In Situ Generated Crude Trithiocarbonate for Visible Light-Mediated RAFT Polymerization of Acrylates. ChemistrySelect 2021, 6:13270–13276.
11.Facile Fabrication of Biobased Hydrogel from Natural Resources: L-Cysteine, Itaconic Anhydride, and Chitosan. ACS Sustainable Chemistry & Engineering, 2020. 2020, 8:4941−4947.
12. Deltex-1 is indispensible for the IL-6 and TGF-β treatment-triggered differentiation of Th17 cells. Cell Immunol, 2020
13. Rho-ROCK signaling mediates entotic cell death in tumor. Cell Death Discov, 2020 Jan 23;6:4
14. Commentary: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Front Immunol, 2020,
15. Biocompatibility and cytotoxicity of novel photoinitiator π-conjugated dithienophosphole derivatives and their triggered polymers. Toxicol In Vitro, 2020 Mar;63:104720.
16. Commentary: Metabolites released from apoptotic cells act as tissue messengers. Front Immunol, 2020,
17. 1,2-Diketones as Photoinitiators of both Cationic and Free-Radical Photopolymerization under UV (392 nm) or Blue (455 nm) LEDs. J Polymer Sci, 2020. DOI: 10.1002/pol.20190157
18. Recent advances in light-regulated non-radical polymerisations.Chem Soc Rev. 2020, 49(6):1867-1886.
19. Peripheral RAFT Polymerization on a Covalent Organic Polymer With Enhanced Aqueous Compatibility for Controlled Generation of Singlet Oxygen. Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10431-10435.
20. Facile Fabrication of Biobased Hydrogel from Natural Resources: L-Cysteine, Itaconic Anhydride, and Chitosan. ACS Sustainable Chemistry & Engineering, 2020.
21. ILC3 function as a double-edged sword in inflammatory bowel diseases. Cell Death Dis, 2019 ;10(4):315.
22. Novel Immune Microlens Imaging for Detection of Antigen and Antibody. J Immunol Res, 2019:5474519.
23. Commentary: Regulatory Innate Lymphoid Cells ControlInnate Intestinal Inflammation. Front Immunol. 2018, 2;9:1522.
24. ICBP90mediates Notch signaling to facilitate human hepatocellular carcinoma growth.Tissue and Cell, 2018, 54: 65-71.
25. Garlic-derivedcompound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wntpathway. Acta Pharmaceutica Sinica B. 2018,8(4):575-586.
26.Hints in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death. Cell Death Differ, 2017,doi:10.1038/cdd.2017.24
27.LncRNA HANR Promotes Tumorigenesis and Increase of Chemoresistance inHepatocellular Carcinoma. Cell Physiol Biochem, 2017;43(5):1926-1938
28.E2F8is a potential therapeutic target for hepatocellular carcinoma. J Cancer, 2017,doi:10.7150/jca.18255
29.microRNAlet-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells bylinking JNK1/2 to AP-1/STAT1/STAT3 signalin130.Sci Rep. 2016; 6:24434. doi: 10.1038/srep24434
31.Antizymeinhibitor 1: a potential carcinogenic molecule. Cancer Sci, 2016 Nov 21. doi:10.1111/cas.13122
32. Role of CSL-dependent and independent Notch signalingpathways in cell apoptosis. Apoptosis. 2016 Jan;21(1):1-12. doi:10.1007/s10495-015-1188-z.
33. Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep, 2015;5:8234. doi: 10.1038/srep08234.
34. Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Sci Rep, 2015;5:11100. doi: 10.1038/srep11100.
35. Novel Functionalized Selenium Nanoparticles for Enhanced Anti-Hepatocarcinoma Activity In vitro. Nanoscale Res Lett. 2015;10(1):1051. doi: 10.1186/s11671-015-1051-8.
36. A novel antioxidant multi-target iron chelator M30 protects hepatocytes against ethanol-induced injury. Oxid Med Cell Longev, 2015;2015:607271. doi: 10.1155/2015/607271.
37.Bee’s honey attenuates non alcoholic steatohepatitis induced hepatic injury through the regulation of thioredoxin interacting protein–NLRP3 inflammasome pathway. Eur J Nutr, DOI 10.1007/s00394-015-0964-4
38.Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy. Cell Transplant, 2015;24(3):419-28.
39.Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Sci Rep, 2014;4:5587. doi: 10.1038/srep05587.
40.Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration. Sci Rep, 2014;4:7601. doi: 10.1038/srep07601.
41.ZeaxanthinDipalmitate Therapeutically Improves Hepatic Functions in an AlcoholicFatty Liver Disease Model through Modulating MAPK Pathway. PLOS ONE, 2014;9(4):e95214. doi: 10.1371/journal.pone.0095214.
42. Ionomycin inhibits Jurkat T cell behaviors in the presence of phorbol-12,13-dibutyrate. Ann Hematol, 2014,93(5):735-46.
43.Sp1 modification of human endothelial nitric oxide synthase promoter increases the hypoxia-stimulated activity. Microvasc Res, 2014, 93(3):80-86.
44.Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. Int J Biol Macromol, 2014, 69:73-78.
45.p38α subtype is a potential target to inhibit eNOS activity and NO production in human endothelial cells. Microvasc Res, 2014,91, 58–65.
46.Landmark papers written by the Nobelists in physics from 1901 to 2012: a bibliometric analysis of their citations and journals. Scientometrics, 2014, 100: 329-338
47.Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury. Toxicol Sci, 2014 Nov 27. pii: kfu244. [Epub ahead of print]
48.PI3K pathway inhibitor LY294002 alters Jurkat T cell biobehaviors via ERK1/2–ICBP90 mediation. Cent Eur J Biol, 2014, 9(8):739-748.
49.Jagged-1–Hes-1 signaling inhibits the differentiation of Th17 cells via RORγt. J Biol Reg Homeos Ag, 2013,27(1):79-93.
50.Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins. Pharmacol Rep, 2013,65(2):435-444.
51.In vitro and in vivo evaluation of anisomycin against Ehrlich ascites carcinoma. Oncol Rep, 2013, 29(6):2227-2236.
52.Hes-1-targeting siRNA inhibits the maturation of murine myeloid-derived dendritic cells. Cent Eur J Biol,2013,8(11),1102-1111.
53.Bibliometric analysis of Nobelists’ awards and landmark papers in physiology or medince during 1983-2012. Ann Med, 2013,45(8):532-8.
54.Low-dose anisomycin is sufficient to alter the bio-behaviors of Jurkat T cells. Cent Eur J Biol, 2013, 8(12), 1230-1240
55.Hepatic Lipid Metabolism and Herbal Impacts on Non-Alcoholic Fatty Liver Disease. J Food Nutr Disor, 2013, 2:4
56.In vivo toxicological evaluation of Anisomycin. Toxicol Lett 2012, 208(1):1-11.
57.Comparison of immature and mature bone marrow-derived dendritic cells by atomic force microscopy. Nanoscale Res Lett, 2011,6(1):455-466.
58.Nano-characterization of Jagged-1-educated dendritic cells. Cent Eur J Biol, 2011,6(6), 981-989
59.Lysophosphatidylcholine Up-regulates Human Endothelial Nitric Oxide Synthase Gene Transactivity by c-Jun N-terminal Kinase Signaling Pathway. J Cell Mol Med, 2009, 13(6):1136-1148
60.ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells. Cell Immunol, 2009, 257:80-87
61.Anisomycin Inhibits the Behaviors of T Lymphocytes and the Allogeneic Skin Transplantation in Mice. J Immunother, 2008, 31(9):858-870
62. Inconvenient role of human hTSLP-educated DCs. Cell Mol Immunol, 2008, 5(2):99-106
63.Soluble Jagged-1 chimera protein induces the differentiation and maturation of bone marrow-derived dendritic cells. Chinese Sci Bull, 2008, 53(7):1040-1048
64.A novel subset of interferon-producing killer dendritic cells. Sci China Ser C-Life Sci, 2008,51(8):671-675
65.Soluble Jagged-1/Fc chimera protein induces the differentiation of lymphonode cells into CD4+CD25+ T cells. Prog Biochem Biophys，2008, 35(6):676-683
66.The activation of ERK3 signaling pathway blocks cell proliferation. Prog Biochem Biophys，2007,34(2):117-123
67.Role of AP1 element in the activation of human eNOS Promoter by lysophosphatidycholine. J Cell Biochem, 2006, 98(4):872–884
68.Down-regulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation. Biochem Cell Boil, 2006, 84(5): 780-788
二．申请与授权的专利
1. 一种半成熟树突状细胞的体外制备方法，排名一，发明专利, ZL201110032089.6
2. 一种人血管eNOS基因启动子改构体及其制备方法和应用，排名一，发明专利, ZL201110075126.1
3. 一种靶向抗肝癌纳米粒子及其制备方法和应用, 排名一，发明专利, ZL201410209779.8
4. 一种细菌源性吡咯烷类化合物在制备免疫抑制剂中的应用, 排名一，发明专利, CN104127408A
5. 一种细菌源性抗生素在制备抗肿瘤药物中的应用，排名一，发明专利, CN104161753A
6. SAMC的新用途,排名二, 发明专利,CN105147655A
三．承担的主要项目
1. Jagged-1基因修饰未成熟DC诱导同种特异性皮肤和心脏移植免疫耐受及其机制，国家自然科学基金项目（主持）
2. Jagged-1在Th17细胞分化中的作用及其机制，国家自然科学基金项目（主持）
3. Anisomycin抑制T细胞的机制、应用及靶点，国家自然科学基金项目，（主持）
4. TORCH四项免疫微球检测系统的开发与产业化，广州市协同创新重大专项，400万（主持）
5. 广东省教育厅专项经费390万（主持）
6. 中央高校专项经费80万（主持）
