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2017年11月22日 星期三 农历壬辰年
师资队伍
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研究生导师
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中初级
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邢飞跃教授
 

邢飞跃,医学博士,组织移植与免疫研究中心教授,博士生导师,组织移植与免疫研究中心/免疫生物学系主任。曾受训于中国医学科学院药物研究所韩锐教授和第一军医大学赵克森教授,在印度Bose Institute免疫学系做Research Scientist,在美国Duke University医学中心担任Protocol Principal Investigator。长期以来一直致力于通过基因表达调控与干预策略和细胞信号转导技术,探讨肿瘤免疫与肿瘤药物靶向治疗,移植免疫与免疫耐受和自身免疫性疾病的分子机制及其治疗新法。曾主持完成国家自然科学基金项目、省自然科学基金项目、省优秀科技人才专项基金项目9项,主要参与完成美国NIH RO1和R21项目3项,在国内外专业杂志上发表论文150余篇,参编专著和本科教材5部,培养硕、博士生43名。曾获省科技进步二等奖1项(排名第一),其它省科技进步奖多项(排名第一至第四)。为国家“863”项目、国家自然科学基金项目、教育部高校博士点基金项目、广东省自然科学基金项目和广州市科技攻关项目评审专家,广东省免疫学会常务理事,广东省生物物理学会常务理事;兼任Clin J Allergy ImmunolAm J Curr BiolAm J Mol Cell BiologySOJ ImmunologyInt J Med Med Sci和Int J Hematol Res等国际专业杂志编委;是Cell Death Dis、J Cell BiochemBiochem Cell BiolCell ImmunolPlos OneClin  Exp Pharmacol PhysiolMaterials Science & Engineering C、Expert Review of Gastroenterology & Hepatology、Prog Biochem Biophys、Acta Biochim Biophys Sin和Chinese Med等杂志审稿人美国免疫学家学会和美国生物化学与分子生物学学会会员。主要享有省政府特殊津贴,省卫生科技先进工作者,省第二届青年科技奖,市科技进步先进工作者和市优秀青年科技工作者等荣誉。

一.在SCI杂志上发表的主要论文

1.Hints in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death. Cell Death Differ, 2017,doi:10.1038/cdd.2017.24

2.E2F8is a potential therapeutic target for hepatocellular carcinoma. J Cancer, 2017,doi:10.7150/jca.18255

3.microRNAlet-7c is essential for the anisomycin-elicited apoptosis in Jurkat T cells bylinking JNK1/2 to AP-1/STAT1/STAT3 signaling.Sci Rep. 2016; 6:24434. doi: 10.1038/srep24434

4.Antizymeinhibitor 1: a potential carcinogenic molecule. Cancer Sci, 2016 Nov 21. doi:10.1111/cas.13122

5. Role of CSL-dependent and independent Notch signalingpathways in cell apoptosis. Apoptosis. 2016 Jan;21(1):1-12. doi:10.1007/s10495-015-1188-z.

6. Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep, 2015;5:8234. doi: 10.1038/srep08234.

7. Antioxidant treatment enhances human mesenchymal stem cell anti-stress ability and therapeutic efficacy in an acute liver failure model. Sci Rep, 2015;5:11100. doi: 10.1038/srep11100.

8. Novel Functionalized Selenium Nanoparticles for Enhanced Anti-Hepatocarcinoma Activity In vitro. Nanoscale Res Lett. 2015;10(1):1051. doi: 10.1186/s11671-015-1051-8.

9.  A novel antioxidant multi-target iron chelator M30 protects hepatocytes against ethanol-induced injury. Oxid Med Cell Longev, 2015;2015:607271. doi: 10.1155/2015/607271.

10.Bee’s honey attenuates nonalcoholic steatohepatitisinduced hepatic injury through the regulation of thioredoxininteracting protein–NLRP3 inflammasome pathway. Eur J Nutr, DOI 10.1007/s00394-015-0964-4

11. Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy. Cell Transplant, 2015;24(3):419-28.

12. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Sci Rep, 2014;4:5587. doi: 10.1038/srep05587.

13. Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration. Sci Rep, 2014;4:7601. doi: 10.1038/srep07601.

14. ZeaxanthinDipalmitate Therapeutically Improves Hepatic Functions in an AlcoholicFatty Liver Disease Model through Modulating MAPK Pathway. PLOS ONE, 2014;9(4):e95214. doi: 10.1371/journal.pone.0095214.

15. Ionomycin inhibits Jurkat T cell behaviors in the presence of phorbol-12,13-dibutyrate. Ann Hematol, 2014,93(5):735-46.

16. Sp1 modification of human endothelial nitric oxide synthase promoter increases the hypoxia-stimulated activity. Microvasc Res, 2014, 93(3):80-86.

17. Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway. Int J Biol Macromol, 2014, 69:73-78.

18.  p38α subtype is a potential target to inhibit eNOS activity and NO production in human endothelial cells. Microvasc Res, 2014,91, 58–65.

19.  Landmark papers written by the Nobelists in physics from 1901 to 2012: a bibliometric analysis of their citations and journals. Scientometrics, 2014, 100: 329-338

20.  Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury. Toxicol Sci, 2014 Nov 27. pii: kfu244. [Epub ahead of print]

21. PI3K pathway inhibitor LY294002 alters Jurkat T cell biobehaviors via ERK1/2–ICBP90 mediation. Cent Eur J Biol, 2014, 9(8):739-748.

22. Jagged-1–Hes-1 signaling inhibits the differentiation of Th17 cells via RORγt. J Biol Reg Homeos Ag, 2013,27(1):79-93.

23. Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins. Pharmacol Rep, 2013,65(2):435-444.

20. In vitro and in vivo evaluation of anisomycin against Ehrlich ascites carcinoma. Oncol Rep, 2013, 29(6):2227-2236.

24. Hes-1-targeting siRNA inhibits the maturation of murine myeloid-derived dendritic cells. Cent Eur J Biol,2013,8(11),1102-1111.

25. Bibliometric analysis of Nobelists’ awards and landmark papers in physiology or medince during 1983-2012. Ann Med, 2013,45(8):532-8.

26. Low-dose anisomycin is sufficient to alter the bio-behaviors of Jurkat T cells. Cent Eur J Biol, 2013, 8(12), 1230-1240

27. Hepatic Lipid Metabolism and Herbal Impacts on Non-Alcoholic Fatty Liver Disease. J Food Nutr Disor, 2013, 2:4

28. In vivo toxicological evaluation of Anisomycin. Toxicol Lett 2012, 208(1):1-11.

29. Comparison of immature and mature bone marrow-derived dendritic cells by atomic force   microscopy. Nanoscale Res Lett, 2011,6(1):455-466.

30. Nano-characterization of Jagged-1-educated dendritic cells. Cent Eur J Biol, 2011,6(6), 981-989

31. Lysophosphatidylcholine Up-regulates Human Endothelial Nitric Oxide Synthase Gene Transactivity by c-Jun N-terminal Kinase Signaling Pathway. J Cell Mol Med, 2009, 13(6):1136-1148

32. ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells. Cell Immunol, 2009, 257:80-87

33. Anisomycin Inhibits the Behaviors of T Lymphocytes and the Allogeneic Skin Transplantation in Mice. J Immunother, 2008, 31(9):858-870

34. Inconvenient role of human hTSLP-educated DCs. Cell Mol Immunol, 2008, 5(2):99-106

35. Soluble Jagged-1 chimera protein induces the differentiation and maturation of bone marrow-derived dendritic cells. Chinese Sci Bull, 2008, 53(7):1040-1048

36. A novel subset of interferon-producing killer dendritic cells. Sci China Ser C-Life Sci, 2008,51(8):671-675

37. Soluble Jagged-1/Fc chimera protein induces the differentiation of lymphonode cells into CD4+CD25+ T cells. Prog Biochem Biophys2008, 35(6):676-683

38. The activation of ERK3 signaling pathway blocks cell proliferation. Prog Biochem Biophys2007,34(2):117-123

39. Role of AP1 element in the activation of human eNOS Promoter by lysophosphatidycholine. J Cell Biochem, 2006, 98(4):872–884

40. Down-regulation of human endothelial nitric oxide synthase promoter activity by p38 mitogen-activated protein kinase activation. Biochem Cell Boil, 2006, 84(5): 780-788

二.申请与授权的专利

1.  一种半成熟树突状细胞的体外制备方法,排名一,发明专利, ZL201110032089.6

2.  一种人血管eNOS基因启动子改构体及其制备方法和应用,排名一,发明专利, ZL201110075126.1

3.  一种靶向抗肝癌纳米粒子及其制备方法和应用, 排名一,发明专利, ZL201410209779.8

4.  一种细菌源性吡咯烷类化合物在制备免疫抑制剂中的应用, 排名一,发明专利, CN104127408A

5.  一种细菌源性抗生素在制备抗肿瘤药物中的应用,排名一,发明专利, CN104161753A

三.承担的主要项目

1.  Jagged-1基因修饰未成熟DC诱导同种特异性皮肤和心脏移植免疫耐受及其机制,国家自然科学基金项目(主持);

2.  Jagged-1Th17细胞分化中的作用及其机制,国家自然科学基金项目(主持);

3.  Anisomycin抑制T细胞的机制、应用及靶点,国家自然科学基金项目,55万(主持);

4.   TORCH四项免疫微球检测系统的开发与产业化,广州市协同创新重大专项,200万(主持)。


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